Filaggrin anticorps (AA 198-288)

N° du produit ABIN5707859

Cet anticorps Lapin Monoclonal détecte spécifiquement Filaggrin dans IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour Filaggrin anticorps (AA 198-288) (ABIN5707859)

Antigène: Filaggrin (FLG)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Filaggrin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FLG-1957R

Détail du produit anti-Filaggrin anticorps

Épitope: AA 198-288

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: Amino acids 198-288 of human Filaggrin were used as the immunogen for this recombinant FLG antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant FLG antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant FLG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Filaggrin

Antigène: Filaggrin (FLG)

Autre désignation: Filaggrin

Sujet: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Pathways: Sensory Perception of Sound, Stem Cell Maintenance